Los Angeles — Fans worldwide are expressing concern after Emmy-winning actress Christina Applegate, 53, was hospitalized with a severe kidney infection that doctors say has spread to both kidneys, causing extreme pain and posing a serious risk to her health.

The beloved star of Married… with Children and Dead to Me has already been facing immense personal challenges, having been diagnosed with multiple sclerosis (MS) in 2021 — a chronic illness that affects the central nervous system and can cause fatigue, mobility issues, and muscle weakness.

According to a family source, the medical emergency began earlier this week when Applegate developed intense lower back pain, fever, and nausea. Initially believing it to be a minor infection, she sought outpatient treatment — but within 24 hours, her symptoms worsened dramatically.

Paramedics rushed her to Cedars-Sinai Medical Center, where tests confirmed the infection had spread to both kidneys. She was immediately placed on high-dose intravenous antibiotics and is now under round-the-clock monitoring in a private hospital room.

“This is a dangerous situation,” a source close to the actress said. “Kidney infections can escalate quickly, especially when someone’s immune system is already compromised. Christina is in a lot of pain, but she’s fighting.”

Doctors have stressed that while her condition is serious, early intervention has improved her chances of recovery. However, the combination of MS and a severe infection means her body is under extraordinary stress, and there is a heightened risk of complications.

Friends from the entertainment industry have reached out with messages of love and support, including several former co-stars who have described her as “one of the toughest people” they know.

Applegate has been open with fans about her MS journey, often using humor and honesty to raise awareness about the disease. But in light of this latest health battle, her team has asked for privacy while she focuses on recovery.

“She’s incredibly strong,” the family source added. “But she needs rest, she needs care, and she needs time. Everyone is praying for her.”

As of now, doctors are cautiously optimistic, though they have warned that recovery could take several weeks. Fans have flooded social media with messages, photos, and memories of her career, hoping to lift her spirits during this challenging time.